Synthesis and Characterization of "Sweet" Salicyla..., 2012

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Title
Synthesis and Characterization of "Sweet" Salicylate Drugtrees.
Date
2012
Material Type
Undergraduate Research; Report
Creator/Author
Wims, Darnell T.
Copyright
Copyright 2012 by Darnell T. Wims. This material is copyrighted and any further reproduction or distribution is prohibited without the permission of the copyright owner.
Subject
Salicylates; Nonsteroidal anti-inflammatory agents; Dendrimers in medicine;
Description
Non-steroidal anti-inflammatory drugs (NSAIDs) are common over-the-counter drugs with anti-inflammatory, analgesic and antipyretic effects. These drugs normally require large doses to have therapeutic effects because of low water solubility, which induces adverse side effects (e.g., stomach ulcers and bleeding) after long term use. Small molecular drugs like NSAIDs also need to be taken several times daily in order to sustain their remedial effects. This research will developed a way to improve the solubility of salicylic acid, a common NSAID, by conjugating water-soluble galactose (sugar commonly found in diary product, etc.) with it to make so called “sweet” salicylic acid. In order to extend the medical effect of salicylic acid, dendritic (or tree-like) architecture has been used to incorporate multiple salicylic acid molecules into a drug tree to give a slow controlled release of the drugs. Based on the previous work on the synthesis of dendritic salicylic acid drugs, a modified synthetic protocol will be utilized to put the “sweet” salicylic acids on the surface of the salicylic acid dendrimers. The products thus far have been characterized using NMR (Nuclear Magnetic Resonance). McNair Scholar project. Faculty Advisor: Minghui Chai, Chemistry.
Language
English
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